This followed a study that found that a single milligram dose might affect the heart's rhythm, leading to QT interval prolongation. This dose, however, is no longer available and is much higher than the 2 milligrams to 8 milligrams that children and teens typically are prescribed.
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Phenergan package insert. Droperidol and ondansetron-induced QT interval prolongation: A clinical drug interaction study. Cheng A. Emergency department use of oral ondansetron for acute gastroenteritis-related vomiting in infants and children.
Phenergan Package Insert. Zofran Prescribing Information. Antiemetics for reducing vomiting related to acute gastroenteritis in children and adolescents.
Cochrane Database of Systematic Reviews. July Impact of increasing ondansetron use on clinical outcomes in children with gastroenteritis. JAMA Pediatrics. Your Privacy Rights. To change or withdraw your consent choices for VerywellHealth. At any time, you can update your settings through the "EU Privacy" link at the bottom of any page. These choices will be signaled globally to our partners and will not affect browsing data. We and our partners process data to: Actively scan device characteristics for identification.
I Accept Show Purposes. Table of Contents View All. They never tried Phenergan or Reglan or anything else. When I had some nausea that threatened to take me out of a show that I really, really needed to be in, my doctor called in a Zofran prescription for me as well -- and my dosage is the same as my pound daughter's.
So part of me thinks that it has to be pretty dang safe once you get past the first dose. I think your emetiphobia may be influencing your analysis of why you got better faster - maybe you have a more robust immune system, maybe you got a milder strain than they did. I was with a bicycle team in Cuba years ago where we all got hit with a norovirus on arrival, and it hit everyone differently. I was sick for days but never fainted.
My Dad's first symptom was when he passed out, but by the next day he was back to normal. In the medical world, Zofran is used extremely commonly, particularly in the emergency department. It is really no longer just for chemo-induced nausea - it is regularly used for simple gastroenteritis and I often see it used as first line by obstetricians for nausea of pregnancy, even though vitamin B6 and doxylamine an over the counter antihistamine are cheaper recommended first line agents.
It is absolutely one of my top 5 most prescribed medications. Phenergan, Compazine, and Reglan are also great anti-nausea drugs, but they also have some pretty unfortunate side effects for some people.
On the other hand, I've given literally thousands of doses of Zofran and I've never seen a single side effect from it. It's true that prolonged QT can cause a fatal arrhythmia, but I actually agree with you - plenty of things sold over the counter can kill you.
Zofran is just as safe as many if not most over the counter medications. It should be over the counter. I wouldn't be surprised if it is available over the counter within the next 10 years. I'd lose a lot of business but I wouldn't mind! Hmmm, we'll see who is right. Because I kind of expect it to be even more restricted as I said. It is possible we could both be right. Still, Zofran is such a popular medication, and it has far more utility than the coxibs. I should note that I just realized that the comment linked in the question was my own, so I just repeated myself to some extent - obviously this is just my opinion as one doctor who sees a lot of people for whom Zofran is a useful treatment.
But based on patterns I've seen in the past 5 years, I definitely feel it's being prescribed more freely as physicians who trained since it went generic go into practice, and I believe that trend will continue even if a boxed warning came out for it. But there is a not insignificant subsegment of the population who would be at risk with a much smaller dose, namely, people with congenital QT prolongation not all of whom are aware they have this problem and people on other medications that prolong the QT, such as methadone, hydrochlorothiazide, and furosemide - all very common prescription meds, and as you saw, there are many more examples.
This is part of the reason why prescription meds that combine Tylenol with other pain medications recently got a black box warning. People take multiple Tylenol-containing medications without realizing it too frequently, and the resulting liver failure can be fatal.
The FDA has to take into account the fact that we have an aging and diverse populace who would be accessing these meds if they were over the counter, we can't expect most people to know whether their combination of medications would be likely to produce a dangerous QT change. Dystonic reactions are rare, but can occur with a regular dose of Zofran or other prescription anti-emetics and certain other classes of prescription medications.
Generic Zofran is still incredibly expensive. Actually, the last time I checked, which was admittedly a couple of years ago, a month's supply of generic Zofran for 8 mg tabs was more than a thousand dollars! Ondansetron works by blocking serotonin, a natural substance in the brain that can trigger nausea and vomiting. The U. To make sure ondansetron is safe for you, tell your doctor if you have:. Ondansetron is not expected to harm an unborn baby.
Tell your doctor if you are pregnant. It is not known whether ondansetron passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby. Ondansetron is not approved for use by anyone younger than 4 years old. Ondansetron orally disintegrating tablets may contain phenylalanine. Tell your doctor if you have phenylketonuria PKU. Get emergency medical help if you have signs of an allergic reaction: rash, hives; fever, chills, difficult breathing; swelling of your face, lips, tongue, or throat.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. Ondansetron may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert. Use Ondansetron Zofran exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.
Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended. The first dose of ondansetron is usually taken before the start of your surgery, chemotherapy, or radiation treatment.
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